Clinical References, Evidence & Validation.

Ideal lesion characteristics, device description, & lesion size of NIMBUS MEE

Clinical advantages v. conventional technique, reducing procedure time by 50%

Comparison of Lesion Volumes & Shapes Produced with Cooled, Protruding, & Standard RFA

Characterizes the size & shape of the NIMBUS MEE lesion as 467 mm3

Perpendicular placement of NIMBUS MEE for lumbar MRI validated to be 601 mm3

Bench science & post-procedure MRI validation of size & shape of strip lesion for SIJ RFA

Case report with MRI validating the size & shape of strip lesion for SIJ neurotomy

12 month outcomes in 182 patients utilizing NIMBUS MEE for SIJ RFA

SIJ innervation from S1–S3 LBs varies and benefits from a large-volume lesion

Coaxial (94 p.) to Multifidus Sparing (401 p.) Lumbar RFA with >56% of patients reporting positive outcome at 1 year

Significant pain reduction sustained up to 9 months with ultrasound-guided RFA using NIMBUS MEE

Advancements in RF technology, including NIMBUS Multitined Expandable Electrode

Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group

Supports either multiple lesions or large volume lesion

12 month outcomes in 182 patients utilizing NIMBUS MEE for SIJ RFA

Statistically significant decrease in pain intensity were observed at up to 24 months

Parallel Placement is Technically Challenging - L4 was 31.04º ± 1.83º & L5 was 40.74º ± 1.86º

Muscle-Bone Interface in Ex-Vivo Model Comparison

Advanced Interventional Procedures for Knee Osteoarthritis

Image-guided technique for targeting the infrapatellar branch of the saphenous nerve

Review of Sacral anatomy, diagnosis, & RFA techniques

At a mean follow-up of 9.0 ± 1.5 months, 50.0% reported ≥50% NRS reduction and 56.3% reported PGIC scores ≥6

≥50% NPRS reduction reported by 55.6% of participants at a mean follow-up of 13.1 months

Larger lesions increase the likelihood of capturing the targeted structure